Graphical models for multivariate time series from intensive care monitoring.

نویسندگان

  • Ursula Gather
  • Michael Imhoff
  • Roland Fried
چکیده

Nowadays physicians are confronted with high-dimensional data generated by clinical information systems. The proper extraction and interpretation of the information contained in such massive data sets, which are often observed with high sampling frequencies, can hardly be done by experience only. This yields new perspectives of data recording and also sets a new challenge for statistical methodology. Recently graphical models have been developed for analysing the partial correlations between the components of multivariate time series. We apply this technique to the haemodynamic system of critically ill patients monitored in intensive care. In this way we can appraise the practical value of the new procedure by re-identifying known associations within the haemodynamic system. From separate analyses for different pathophysiological states we can even conclude that distinct clinical states are characterized by distinct partial correlation structures. Hence, this technique seems useful for automatic statistical analysis of high-dimensional physiological time series and it can provide new insights into physiological mechanisms. Moreover, we can use it to achieve an adequate dimension reduction of the variables needed for online monitoring at the bedside.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Analysis of High Dimensional Datafrom Intensive Care

As high dimensional data occur as a rule rather than an exception in critical care today, it is of utmost importance to improve acquisition, storage, modelling, and analysis of medical data, which appears feasable only with the help of bedside computers. The use of clinical information systems ooers new perspectives of data recording and also causes a new challenge for statistical methodology. ...

متن کامل

Using Bayesian Networks and Rule-Based Trending to Predict Patient Status in the Intensive Care Unit

Multivariate Bayesian models trained with machine learning, in conjunction with rule-based time-series statistical techniques, are explored for the purpose of improving patient monitoring. Three vital sign data streams and known outcomes for 36 intensive care unit (ICU) patients were captured retrospectively and used to train a set of Bayesian net models and to construct time-series models. Mod...

متن کامل

Robust and Adaptive Filtering of Multivariate Online-Monitoring Time Series

We propose a new regression-based filter for multivariate time series that separates signals from noise and outliers in real time. The new method merges the advantageous properties of two existent filtering procedures for online-monitoring time series. Our multivariate and robust procedure yields signal estimations at the right end point of a moving time window whose width is adapted to the cur...

متن کامل

Graphical modelling for multivariate time series

Graphical models for multivariate time series is a concept extended by Dahlhaus (2000) from a random vector to a time series. We propose a test statistic to identify a graphical model for multivariate time series with the Kullback-Leibler distance between two spectral density matrices characterized by graphical models. Asymptotic null distribution is derived to be normal with the mean and varia...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Statistics in medicine

دوره 21 18  شماره 

صفحات  -

تاریخ انتشار 2002